BiostatR Blog

Let X, one observation composed of two values (x1, x2) obtained from Gaussian distributions µ1, s1 and µ2, s2 with rho being a correlation coefficient between Gaussian distributions 1 and 2, the likelihood is: library(mvtnorm) dmvnorm(x=c(x1,x2), mean=c(µ1,µ2), sigma=matrix(c(s1, rho, rho, s2), ncol=2))

 These options seem to be ok: ```{r setup, include=TRUE} knitr::opts_chunk$set(fig.path='figs/xxx_',                        dev='svg',                        concordance=TRUE,                        echo=TRUE,                        fig.width=12, fig.height=8,                        dev.args=list(pointsize=16)) ```

 MacOSX 15.3 gcc installed using MacBrew I get this error: ld: warning: search path '/opt/gfortran/lib/gcc/aarch64-apple-darwin20.0/12.2.0' not found ld: warning: search path '/opt/gfortran/lib' not found ld: library 'gfortran' not found I solve it by creating a  ~/.R/Makevars  file like this: FC      = /opt/homebrew/opt/gfortran/bin/gfortran F77     = /opt/homebrew/opt/gfortran/bin/gfortran FLIBS   = -L/opt/homebrew/opt/gfortran/lib Now I can compile package with gfortran

 Since this morning (5/2/2025), I get an error when I try to load optimx package: > library("optimx") Erreur : le chargement du package ou de l'espace de noms a échoué pour ‘optimx’ in dyn.load(file, DLLpath = DLLpath, ...) : impossible de charger l'objet partagé '/Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/library/nloptr/libs/nloptr.so' :   dlopen(/Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/library/nloptr/libs/nloptr.so, 0x0006): Library not loaded: /opt/homebrew/opt/nlopt/lib/libnlopt.0.dylib   Referenced from: <2A7DAFE2-8123-3555-9569-F28214328E47> /Library/Frameworks/R.framework/Versions/4.4-arm64/Resources/library/nloptr/libs/nloptr.so   Reason: tried: '/opt/homebrew/opt/nlopt/lib/libnlopt.0.dylib' (no such file), '/System/Volumes/Preboot/Cryptexes/OS/opt/homebrew/opt/nlopt/lib/libnlopt.0.dylib' (no such file), '/opt/homebrew/opt/nlopt/lib/libnlopt.0.dylib' (no such file), '/Libra...

main = expression("Temperature ("*~degree*C*")") main = "Temperature (°C)" main = "Temperature (\u00B0C)" with expression format, the font is lighter. I don't know why.